Estimation of risk based on multiple events in radiation carcinogenesis of rat skin.

In the multistage theory of carcinogenesis, cells progress to cancer through a series of discrete, irreversible, heritable genetic alterations or mutations. However data on radiation-induced cancer incidence in rat skin suggests that some part of an intermediate repairable alteration may occur. Data are presented on cancer induction in rat skin exposed to the following radiations: 1. an electron beam (LET=0.34 keV/um, 2. a neon ion beam (LET=25 keV/um and 3. an argon ion beam (LET=125 keV/um. The latter 2 beams were generated by the Bevalac at the Lawrence Berkeley Laboratory, Berkeley, CA. About 6.0 cm2 of skin was irradiated per rat. The rats were observed every 6 weeks for at least 78 weeks and tumors were scored at first occurrence. Several histological types of cancer, including squamous and basal cell carcinomas, were induced. The cancer yield versus radiation dose was fitted by the quadratic equation (Y(D)=CLD+BD2), and the parameters C and B were estimated for each type of radiation. Analysis of the DNA from the electron-induced carcinomas indicated that K-ras and/or c-myc oncogenes were activated in all tumors tested, although only a small proportion of neon-induced tumors showed similar activation. In situ hybridization indicated that the cancers contain subpopulations of cells with differing amounts of c-myc and H-ras amplification. The results are consistent with the idea that ionizing radiation produces carcinogenically relevant lesions via 2 repairable events at low LET and via a non-repairable, linked event pathway at high LET; either pathway may advance the cell by 1 stage in the multistage model. The model, if validated, permits the direct calculation of cancer risk in rat skin in a way that can be subjected to experimental testing.     

Formation of bioorganic compounds in simulated planetary atmospheres by high energy particles or photons.

Various types of organic compounds have been detected in Jupiter, Titan, and cometary coma. It is probable that organic compounds were formed in primitive Earth and Mars atmospheres. Cosmic rays and solar UV are believed to be two major energy sources for organic formation in space. We examined energetics of organic formation in simulated planetary atmospheres. Gas mixtures including a C-source (carbon monoxide or methane) and a N-source (nitrogen or ammonia) was irradiated with the followings: High energy protons or electrons from accelerators, gamma-rays from 60Co, UV light from a deuterium lamp, and soft X-rays or UV light from an electron synchrotron. Amino acids were detected in the products of particles, gamma-rays and soft X-rays irradiation from each gas mixture examined. UV light gave, however, no amino acid precursors in the gas mixture of carbon monoxide, nitrogen and nitrogen. It gave only a trace of them in the gas mixture of carbon monoxide, ammonia and water or that of methane, nitrogen and water. Yield of amino acid precursors by photons greatly depended on their wavelength. These results suggest that nitrogen-containing organic compounds like amino acid precursors were formed chiefly with high energy particles, not UV photons, in Titan or primitive Earth/Mars atmospheres where ammonia is not available as a predominant N-source.     

On small active region filaments,fibrils and surges

High resolution Hα images and magnetograms (0.2 arc s) of an active region were obtained in alternating time series at 42 s cadences using the Swedish 1-m Solar Telescope on 2004 August 21. The Hα filtergrams reveal an active region filament and surges consisting of thread-like structures which have widths similar to the widths of chromospheric fibrils, both recorded down to the resolution limit in the best images. All observed structures in the active region appear highly dynamic. Fibrils show counterstreaming strongly resembling the counterstreaming threads in filaments.     

Coronal Observations of CMEs

CMEs have been observed for over 30 years with a wide variety of instruments. It is now possible to derive detailed and quantitative information on CME morphology, velocity, acceleration and mass. Flares associated with CMEs are observed in X-rays, and several different radio signatures are also seen. Optical and UV spectra of CMEs both on the disk and at the limb provide velocities along the line of sight and diagnostics for temperature, density and composition. From the vast quantity of data we attempt to synthesize the current state of knowledge of the properties of CMEs, along with some specific observed characteristics that illuminate the physical processes occurring during CME eruption. These include the common three-part structures of CMEs, which is generally attributed to compressed material at the leading edge, a low-density magnetic bubble and dense prominence gas. Signatures of shock waves are seen, but the location of these shocks relative to the other structures and the occurrence rate at the heights where Solar Energetic Particles are produced remains controversial. The relationships among CMEs, Moreton waves, EIT waves, and EUV dimming are also cloudy. The close connection between CMEs and flares suggests that magnetic reconnection plays an important role in CME eruption and evolution. We discuss the evidence for reconnection in current sheets from white-light, X-ray, radio and UV observations. Finally, we summarize the requirements for future instrumentation that might answer the outstanding questions and the opportunities that new space-based and ground-based observatories will provide in the future.     

The tenma mission

Tenma, the second X-ray astronomy satellite of Japan launched in February 1983, is outlined. The main instrument of Tenma is a large-area gas scintillation proportional counter array. Some of the highlights of the results thus far obtained are briefly discussed.     

2004年3月13日TC-1和Cluster卫星联合观测的磁通量传输事件

分析了2004年3月13日12:15到12:25UT期间TC-1和Cluster卫星簇的磁通门磁力计(FGM)和电子/电流试验仪(PEACE)的联合观测数据.在此期间,TC-1卫星位于日下点以南的磁层顶附近的磁鞘中,并在12:19UT左右观测到了一个典型的先正后负的磁鞘磁通量传输事件(FTE);而Cluster卫星簇位于北半球日侧高纬磁层项附近,并于12:23UT左右穿出磁层顶进入磁鞘,且在12:21 UT左右也观测到了一个典型的先正后负的磁层FTE.比较分析发现此两个FTE具有类似的磁场结构和等离子体特征,可能是同一个北向运动的FTE先后被TC-1和Cluster卫星观测到.利用Cluster 4颗卫星的多点同时观测数据,采用最小方向微分法和时空微分方法,推断Cluster卫星观测的这个FTE是尺度大小约为1.21Re的准二维结构,其运动方向为东北方向,与Cooling模型预测方向基本一致.利用Cooling模型的预测,推算了TC-1卫星在12:19UT观测的FTE的运动速度和尺度,进而得出随着通量管的极向运动,其速度和尺度均有所增加.     

Histologic effects of high energy electron and proton irradiation of rat brain detected with a silver-degeneration stain.

Application of the degeneration sensitive, cupric-silver staining method to brain sections of male Sprague-Dawley rats irradiated 4 days before sacrifice with 155 Mev protons, 2-8 Gy at 1 Gy/min (N=6) or 22-l0lGy at 20 Gy/min (N=16) or with 18.6 Mev electrons, 32-67 Gy at 20 Gy/min (N=20), doses which elicit behavioral changes (accelerod or conditioned taste aversion), resulted in a display of degeneration of astrocyte-like cell profiles which were not uniformly distributed. Plots of 'degeneration scores' (counts of profiles in 29 areas) vs. dose for the proton and electron irradiations displayed a linear dose response for protons in the range of 2-8 Gy. In the 20-100 Gy range, for both electrons and protons the points were distributed in a broad band suggesting a saturation curve. The dose range in which these astrocyte-like profiles becomes maximal corresponds well with the dose range for the X-ray eradication of a subtype of astrocytes, 'beta astrocytes'.     

Dynamics and structure of ion clouds in the ionosphere from multifrequency doppler sounding

The evolution of a barium ion cloud formed in the MR-20 rocket experiment in the low-latitude ionosphere is considered using data of Doppler multifrequency sounding.     

Analysis of the linear amplifier/analog-digital converter interfacein a digital microwave receiver

An analysis of the relationship between a linear amplifier chain and an analog-to-digital converter (ADC) in a digital microwave receiver, with respect to sensitivity and dynamic range issues, is presented. The effects of gain, third-order intermodulation products and ADC characteristics on the performance of the receiver are illustrated and design criteria for the linear amplifier chain (given a specified ADC) are developed. A computer program is included which calculates theoretical receiver performance based on gain and third-order intermodulation product selections. Experimental results are also presented and compared with theoretical values     

Biological degradation and composition of sweet potato biomass - errata

Many challenges are presented by biological degradation in a bioregenerative Controlled Ecological Life Support System as envisioned by the U.S. National Aeronautics and Space Administration. In studies conducted with biodegradative microorganisms indigenous to sweetpotato fields, it was determined that a particle size of 75 microns and incubation temperature of 30°C were optimal for degradation. The composition of the biomass and characterization of plant nutrient solution indicated the presence of potential energy sources to drive microbial transformations of plant waste. Selected indigenous soil isolates with ligno-cellulolytic or sulfate-reducing ability were utilized in biological studies and demonstrated diversity in their ability to reduce sulfate in solution and to utilize alternative carbon sources: a lignin analog 4-hydroxy, 3-methoxy cinnamic acid, cellulose, arabinose, glucose, sucrose, mannitol, galactose, ascorbic acid.